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Areas of Research

Overactive Bladder (OAB)

Male and Female Urge or Stress Urinary Incontinence

Voiding Dysfunction

Neurourology

Urogynecology/Female Pelvic Medicine and Reconstructive Surgery

Transitional Urology: adults with congenital genitourinary abnormalities

Minimally Invasive Pelvic Surgery: pelvic organ prolapses, urinary fistulas

 

Active Research Projects

 

Brain Control of the Bladder

Our lab's primary research focuses on understanding the brain correlates of the bladder cycle in healthy individuals and in patients with lower urinary tract dysfunction (neurogenic and non-neurogenic). Our team has developed and refined a concurrent urodynamic/fMRI neuroimaging platform to evaluate brain control of bladder filling and voiding where the bladder is filled followed by individuals voiding (or attempt of voiding) actively in the scanner.

Supraspinal Targets in Neurogenic Voiding Dysfunction

As part of an ongoing clinical trial, we have identified brain regions involved at voiding initiation and are investigating the effectiveness of targeted, noninvasive, cortical modulation (using Transcranial Rotating Permanent Magnet Stimulation) in multiple sclerosis (MS) patients to improve their bladder symptoms and restore their brain activation patterns.

Higher Neural Changes following Medications used for Overactive Bladder Management

Our multicenter, double blind, randomized, placebo-controlled trial uses functional magnetic resonance imaging (fMRI) and cognitive testing to evaluate the effects of two commonly used medications for OAB: anticholinergics and β3-adrenergic agonists on brain functional connectivity in females with overactive bladder.

Higher Neural Contribution Underlying Lower Urinary Tract Symptoms in Men with Benign Prostatic Hyperplasia Undergoing Bladder Outlet Procedures

Using our unique multimodal functional Magnetic Resonance Imaging (fMRI) platform, we plan to identify for the first time the structural and functional brain contributions to lower urinary tract symptoms in men with benign prostatic hyperplasia (BPH) at baseline and following bladder outlet obstruction procedures.

Intra-detrusor Injections of Botulinum Toxin-A in Adults with Myelomeningiocele

This study prospectively evaluates both the subjective changes in outcomes and the objective changes in urodynamic parameters after intra-detrusor injections of onabotulinumtoxinA (BTX-A) in adults with congenital spinal dysraphism. This trial is led by Dr. Stampas at TIRR.

Quality of Life after Bladder Surgery in Neurogenic Bladder Patients

This study prospectively evaluates both the subjective changes in outcomes and the objective changes in urodynamic parameters after intra-detrusor injections of onabotulinumtoxinA (Botox®) in adults with congenital spinal dysraphism such as spina bifida.

Transcutaneous Tibial Nerve Stimulation for Acute and Chronic Spinal Cord Injury Neurogenic Bladder

This prospective, longitudinal, multi-institutional assesses the outcomes after reconstructive bladder surgery such as augmentation cystoplasty or urinary diversion. This is a NBRG sponsored trial.

Past Research Projects

Dysport treatment in patients with neurogenic urinary incontinence

Clinical outcomes of patients with congenital genitourinary anomalies, such as spina bifida

Deep brain stimulation in patients with lower urinary tract symptoms

Treatment of overactive bladder with BOTOX® versus tibial nerve stimulation

Assessment of female stress urinary incontinence