Investigating brainstem activation during micturition in healthy individuals
This study will be the one of the first to use high resolution (7-Tesla) functional MRI to evaluate the brain and specifically the brainstem control of bladder function in healthy men and women with a novel and noninvasive MRI paradigm. We are looking for healthy male and female participants over 18 years of age with normal bladder function. Participants will receive a compensation and a 3D printed version of their brain.
Mitigating voiding dysfunction in multiple sclerosis (MS) patients
This study aims to identify brain centers associated with "initiation of voiding" and evaluate the effectiveness of noninvasive, individualized neuromodulation in improving voiding dysfunction symptoms in patients with neurogenic bladder. We're looking for female participants over 18 years of age with clinically stable MS (EDSS ≤ 6.5) and bladder symptoms ≥ 3 months.
Investigating higher neural control in benign prostatic hyperplasia (BPH) patients
Surgical options for bladder outlet obstruction (BOO) are common procedures that offers some lower urinary tract symptomatic improvements in patients with BPH. This study aims to identify structural and functional brain contributions to lower urinary tract symptoms in men with BPH and following BOO procedures. We are looking for male participants 45-90 years old with BPH who plan to undergo a BOO procedure at Houston Methodist Hospital.
Evaluating higher neural change following overactive bladder (OAB) medication
Overactive bladder (OAB) is commonly treated with oral anticholinergic or Beta-3 agonist medication as the first line therapy. This study aims to evaluate for changes in the brain functional connectivity and cognitive network activation in women with OAB after taking either anticholinergic, Beta-3 agonist, or placebo for 30 days, via a visual recognition test. We are looking for female participants 50-90 years old with OAB.
Artificial Urinary Sphincter Clinical Outcomes
The AMS 800 Artificial Urinary Sphincter™ (AUS) is a device used to treat stress urinary incontinence in men. Though it has received official market approval since 1982, incremental technological advancements have been implemented to the device, along with the creation of additional tools to assist with the implantation procedure. This study evaluates the AMS 800 and the AMS tools in men with primary stress urinary incontinence. We are looking for male participants over 18 years of age who plan to undergo an AUS implantation procedure at Houston Methodist Hospital.